Differences in fetal growth, discordancy and placental pathology in reduced vs. non-reduced twins

Abstract

To evaluate the effect of multifetal pregnancy reduction on the incidence of small-for-gestational age (SGA) and discordance in reduced vs non-reduced twins and to examine differences in placental pathology. A computerized ultrasound database was used to identify diamniotic-dichorionic twins who delivered at our institution. Reduced (n=36) vs non-reduced twins(n=243) were compared for differences in rates of SGA and discordancy (>20%). The groups were compared for differences in maternal and neonatal characteristics, as well as differences in placental pathology. Chi-square and stepwise logistic regression were used as appropriate. A comparison of maternal and neonatal characteristics are presented in Table 1. Reduced twins were not found to have a greater incidence of growth discordancy than non-reduced twins. However, there was a trend towards a higher incidence of SGA in reduced vs. non-reduced twins. We found no differences placental path between the 2 groups, p=0.49. Reduced and non-reduced twins have no significant differences in SGA fetuses, growth discordancy, placental pathology or other selected characteristics.Tabled 1MPR vs non MPRMPR twins (%) n=36Non-MPR twins (%) n=243p-valueAge (avg+/-SD)36.7 (4.7)33.2 (6.3)<0.01Parity≥9 (25)71 (29)0.47SGA A610.06SGA B850.33Discordacne20%≥19140.43Preeclampsia19130.31IVF8656<0.01 Open table in a new tab Tabled 1Path MPR vs non MPRPath A+BMPR twins (%) n=34Non-MPR twins (%) n=192Velamentous610Ischemia3850Abruption03Inflammation911 Open table in a new tab