Abstract
Clinical characteristics of patients with falciparum malaria, as well as sensitivity of Plasmodium falciparum to chloroquine and mefloquine, were investigated in 2 distinct strata within the same geographical area of the Amazon Basin. One stratum was the population living along the road, the other that living along the river, both near Rio Branco, capital of Acre State, Brazil. The clinical features did not differ between the 2 strata. Full in vitro sensitivity of P. falciparum to mefloquine was observed in both areas. However, significant differences in chloroquine sensitivity were observed between the 2 strata. EC 50 values for chloroquine were 0·8484 μmol/litre for parasite isolates from the road stratum (E) and 0·4638 μmol/litre for parasite isolates from the river stratum (R). EG 90 values were 2·8095 and 1·2549 μmol/litre in strata ‘E’ and ‘R’, respectively. Continuous drug pressure over years in area ‘E’ and relatively low drug pressure in area ‘R’ were presumably responsible for these differences.
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