Abstract
Background and Objectives: The aim of this study was to compare the differences in compositions of oral and fecal bacterial microbiota between patients with morbid obesity and normal-weight controls. Material and Methods: This was a prospective cohort study. The study included group 1 (patients with BMI ≥ 40 kg/m2) and group 2 (patients with BMI from 18.5 to 24.9 kg/m2). Our endpoint was the analysis of the differences in compositions of oral and fecal microbiota between the groups. Oral swabs and fecal samples were collected from the patients. The analysis of microbiota was conducted using next-generation sequencing. Results: Overall, the study included 96 patients; 52 (54.2%) were included in group 1, 44 (39.8%)—in group 2. In group 1, oral microbiota included significantly more bacteria from genera Veillonella, Oribacterium and Soonwooa, whereas, in group 2, Streptobacillus, Parvimonas and Rothia were more common. Fecal microbiota in group 1 included more Bacteroides, Odoribacter and Blautia and group 2 was more abundant in Ruminococcus, Christensenella and Faecalibacterium. Conclusions: Both oral and fecal gastrointestinal microbiota differs significantly among patients with severe obesity and lean individuals.
Highlights
Published: 30 June 2021The prevalence of obesity has been steadily increasing in the past decades [1,2]
The abnormal gastrointestinal microbiota may play an important role during the development of obesity by multiple mechanisms [10,11]
The aim of this study was to compare the differences in compositions of oral and fecal microbiota between patients with morbid obesity and normal-weight controls to identify bacteria potentially associated with morbid obesity
Summary
Published: 30 June 2021The prevalence of obesity has been steadily increasing in the past decades [1,2]. Various diseases feature a more severe course among patients with obesity. This results in both lower quality of life and increased risk of premature death [5,6]. The microbiota of the digestive tract (microorganisms living in the digestive tract) has become a popular subject of research [7] It is involved in inducing an inflammatory and metabolic response through multiple neural, immune and endocrine pathways [8,9]. The aim of this study was to compare the differences in compositions of oral and fecal bacterial microbiota between patients with morbid obesity and normal-weight controls. Our endpoint was the analysis of the differences in compositions of oral and fecal microbiota between the groups.
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