Differences in clinical features between hepatitis B virus positive and negative patients with primary liver cancer

Abstract

Objective To investigate the differences in clinical features between primary liver can-cer (PLC) patients with positive and negative hepatitis B virus (HBV) and discuss the correlation of positive HBV and TNM staging. Methods Clinicopathological data of 430 patients with primary liver cancer who underwent partial hepatectomy in Henan Cancer Hospital from November 2012 to December 2015 were retrospectively reviewed. The cases were divided into HBV-positive PLC group (n=362) and HBV-negative PLC group (n=68) in according to the HBV infection status. χ2 test was performed to analyze the clinical feature differences of the two groups. Spearman rank correlation was used to assess the differential clinical features and TNM staging of HBV-positive PLC. Results There were statistic differences in gender, age, AFP level, tumor numbers, tumor size, histopathological types and TNM staging between two groups (P<0.05). Furthermore, AFP level, tumor numbers, tumor size and histopathological types showed positive correlation with TNM staging (all P<0.05). Conclusions A number of remarked differences in clinical feature of gender, age, AFP level, tumor numbers, tumor size, histopathological types and TNM staging could be observed in HBV-positive PLC patients compared with HBV-negative patients. HBV-positive PLC patients may have positive correlations of AFP level, tumor numbers, tumor size, histopathological types and TNM staging. Key words: Hepatitis B virus (HBV); Primary liver cancer (PLC); Alpha fetoprotein (AFP); Clinical feature; Cancer staging