Abstract
Mechanical characterization of tissues as being rigid or fluid, and jammed or unjammed, can help describe and understand different mechanical states of these tissue systems in a variety of biological processes such as embryogenesis, tissue regeneration, wound healing, and diseases such as cancer. These mechanical properties of a dense tissue are usually known to be dictated by (1) the migration ability of individual cells, (2) the persistence of cell migration, and (3) a target cell shape index. However, cellular death and division within the tissues, while implicated in broader tissue level dynamics, has been largely left out of consideration when discussing tissue mechanics. In this work we investigate the impact that various triggers of cell death and division impact tissue rigidity, fluidity, jamming and unjamming.
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