Differences in Aerobic Fitness between an Obese Adolescent with Prader-Willi Syndrome and Other Obese Adolescents and Exercise Training Results.

Yentung Su,Minhui Li,Shanghui Tuan,Hungya Huang,Kolong Lin

doi:10.3390/ijerph17051496

Abstract

Prader-Willi syndrome (PWS) is a genetic disorder characterized by specific physical and behavioral abnormalities and considered the most commonly known genetic cause of morbid obesity in children. Recent studies indicate that patients suffering from this syndrome have significant problems in skill acquisition, muscle force, cardiovascular fitness, and activity level. In this study, we report an obese adolescent PWS patient of poor aerobic fitness compared with 13 obesity adolescents, and great improvement in cardiopulmonary exercise test (CPET) outcomes of the PWS patient measured after two weeks of physical exercise training programs.

Highlights

Prader-Willi syndrome (PWS) is a genetic disorder characterized by specific physical and behavioral abnormalities and considered the most commonly known genetic cause of morbid obesity in children
A 17 year old patient with PWS was referred for exercise training programs for poor weight control and obesity
Pre-exercise training cardiopulmonary exercise test (CPET) was done before taking atenolol, post-exercise training CPET was done after taking two weeks of atenolol 50 mg/day

Summary

Case Report

A 17 year old patient with PWS was referred for exercise training programs for poor weight control and obesity. After 2 weeks of exercise training programs, he did CPET again and all aspects of performance improved, with an increase in VO2 and workload at all stages of testing SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; MVV, maximal voluntary ventilation; HRR, heart rate recovery; VO2 , oxygen consumption; WR, work rate; PETCO2, end-tidal carbon dioxide; MET, metabolic equivalent of task; VE, minute ventilation; RER, respiratory exchange ratio. SD, Standard deviation; CI, confidence interval; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; AT, anaerobic threshold; MET, metabolic equivalent of task; HR, heart rate; VE, minute ventilation; HRR, heart rate recovery.

Findings

Discussion

Conclusions