Abstract
In Japan, two 0.4% sodium hyaluronate (HA)-based submucosal injection materials (SIMs) are currently used in endoscopic submucosal dissection (ESD): MucoUp (HA-Mc) and Ksmart (HA-Ks). HA-Mc and HA-Ks have the same concentration and are, thus, construed by most endoscopists to have no difference. Nevertheless, visual observation conveys the impression that HA-Ks have a higher viscosity than HA-Mc, suggesting that HA-Ks performs better than HA-Mc. This study aimed to examine the differences between HA-Mc and HA-Ks. HA-Ks exhibited higher viscosity due to greater weight-average molecular weight compared with HA-Mc. HA-Ks had significantly greater submucosal elevation height (SEH) than HA-Mc; the SEH of HA-Ks-80% (80% dilution of HA-Ks) was the same as that of HA-Mc. The ESD procedure time was significantly shorter with HA-Ks than with HA-Mc (15.2 ± 4.1 vs. 19.5 ± 5.9; P = 0.049). The total injection volume for HA-Ks was significantly lower than that for HA-Mc (10.8 ± 3.6 vs. 14.4 ± 4.6; P = 0.045). However, no significant difference in these items was observed between HA-Mc and HA-Ks-80%. HA-Mc and HA-Ks were considered to be almost the same. Nonetheless, HA-Ks exhibited higher viscosity and SIM performance than HA-Mc. HA-Ks-80% had almost the same performance as HA-Mc. Thus, understanding SIM performance and characteristics requires a focus on the viscosity of SIMs.
Highlights
In Japan, two 0.4% sodium hyaluronate (HA)-based submucosal injection materials (SIMs) are currently used in endoscopic submucosal dissection (ESD): MucoUp (HA-Mc) and Ks Sodium hyaluronate-based submucosal injection material (Ksmart) (HA-Ks)
The present study aimed to examine the differences between HA-Mc and HA-Ks and to demonstrate that understanding SIM performance and characteristics requires a focus on the components, concentrations, and viscosity of SIMs
The evaluation of molecular weight distribution by size exclusion chromatography (SEC) revealed that HA-Ks contained HA with higher weight-average molecular weight than HA-Mc
Summary
In Japan, two 0.4% sodium hyaluronate (HA)-based submucosal injection materials (SIMs) are currently used in endoscopic submucosal dissection (ESD): MucoUp (HA-Mc) and Ksmart (HA-Ks). SIMs based on sodium hyaluronate (HA) were developed in around 2000 and are currently widely used in endoscopic treatments owing to their superior performance and low tissue toxicity[12,13,14]. As HA-Mc and HA-Ks have the same HA concentration, most endoscopists construe that HA-Mc practically does not differ from HA-Ks with respect to viscosity, ease of injection, and SIM performance. Both HA-Mc and HA-Ks are being used and regarded as the same SIM in actual endoscopic treatment
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