Abstract
The dose-dependent inhibition of thrombin stimulated platelet aggregation due to betaadrenoceptor blocking drugs followed the rank order of potency:propranolol >alprenolol > metipranolol and correlated with arachidonic acid ( 3H-AA) liberation. Atenolol which slightly potentiated stimulated aggregation increased also the liberation of 3H-AA from membrane phospholipids of isolated platelets. Stimulation of platelets resulted in decreased 3H-AA incorporation into phosphatidylcholine, phosphatidylinositol and phosphatidic acid and increased incorporation into phosphatidylethanolamine and phosphatidylserine. A 1-prenolol, metipranolol and propranolol enhanced the incorporation of 3H-AA into phosphatidylcholine of stimulated platelets.
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