Difference of Vertical Transmission in HIV-Infected Women with Complete and Incomplete PMTCT

Abstract

Objective: To analyze any differences on vertical transmission in
 groups with complete and incomplete program as well as the factors
 influencing completion.
 
 Method: This was a retrospective cohort study performed by data
 collection from medical records and/or interviews from January
 2010 to February 2012. The variables analyzed subject characteristics,
 applied PMTCT program and risk factors affecting transmission.
 
 Result: Seventy-five pregnant women who were HIV-positive were
 initially recruited, but 21 subjects were excluded due to incomplete
 medical records. In the first group (n=27) who received complete
 PMTCT, no vertical transmission was identified, while in the second
 group (n=27) with incomplete PMTCT, seven children were found to
 be HIV-positive. Rupture of membrane for more than 4 hours was
 the only significant risk factor for vertical transmission (p=0.001,
 RR=64.5, 95% CI=6.14-677.6).
 
 Conclusion: There was a significant difference in the occurrence of
 vertical transmission between complete and incomplete PMTCT
 program. Complete PMTCT program may provide protective effect
 against the occurrence of vertical transmission by 25.9%.
 
 Keywords: HIV, PMTCT, vertical transmission