Abstract
PurposeTo measure the anterior and posterior ocular biometric characteristics concurrently and to explore the relationship between iris, ciliary body and choroid in acute primary angle closure eyes (APAC) and fellow eyes.MethodsIt is a prospective, cross-sectional study. Thirty patients with recent APAC were finally enroled in it. Anterior and posterior uveal parameters were measured simultaneously by anterior segment optical coherence tomography (AS-OCT), swept-source optical coherence tomography (SS-OCT) and ultrasound biomicroscopy (UBM). The parameters were measured including: pupil diameter (PD); iris thickness, curvature (ICURV), area (IAREA); anterior chamber depth (ACD), width (ACW), area (ACA), volume (ACV); lens vault (LV); choroidal thickness and retinal thickness; maximum ciliary body thickness (CBTmax); ciliary body thickness at the point of the scleral spur (CBT0) and 1000 mm away (CBT1000); anterior placement of the ciliary body (APCB); and trabecular-ciliary angle (TCA).ResultsCompared with fellow eyes, APAC eyes had narrower anterior biometric parameters and presented with smaller anterior segment parameters (including ACD and ACW); (p < 0.01)), smaller IAREA and ICURV (p < 0.001), larger LV (p = 0.035), thinner ciliary body and less anterior ciliary process (p < 0.01). After adjustment for potential confounders (axial length, spherical equivalent and PD), APCB was positive correlated with choroidal thickness and CBT, and CBT was positive correlated with choroidal thickness.ConclusionsCompared with fellow eyes, APAC eyes had narrower anterior biometric parameters, thinner ciliary body and smaller iris area and curvature. APCB, CBT and choroidal thickness were positively correlated. However, further studies are required before these conclusions are generalised.
Highlights
Acute primary angle closure (APAC) is characterised by a sudden elevation in intraocular pressure (IOP) accompanied by other findings, such as corneal oedema, a shallow anterior chamber and typical symptoms, such as blurred vision, severe ocular pain or headache, nausea and vomiting
30 Chinese patients (30 pairs of eyes) with unilateral APAC and fellow eyes defined as primary angle closure suspect (PACS) eyes were analyzed
IOP intraocular pressure, D diopter, PD pupil diameter, axial lengths (AL) axial length, CBTmax maximum ciliary body thickness, CBT0 ciliary body thickness at the point of the scleral spur, CBT1000 ciliary body thickness at 1000 μm from the scleral spur, APCB anterior placement of the ciliary body, trabecular-ciliary angle (TCA) the trabecular-ciliary process angle, IT750 iris thickness at 750 μm from the scleral spur, IT2000 iris thickness at 2000 μm from the scleral spur, IAREA iris area, ICURV iris curvature, ACD anterior chamber depth, ACW anterior chamber width, ACA anterior chamber area, ACV anterior chamber volume, LV lens vault, CT choroidal thickness, SD standard deviation, 95% CI 95% confidence interval
Summary
Acute primary angle closure (APAC) is characterised by a sudden elevation in intraocular pressure (IOP) accompanied by other findings, such as corneal oedema, a shallow anterior chamber and typical symptoms, such as blurred vision, severe ocular pain or headache, nausea and vomiting. It is considered an abnormal anatomic disorder [1]. Until recently, no study has attempted concurrent measurement of the anterior and posterior parts of the uvea (iris, ciliary body and choroid) or an evaluation of the relationship between them. The aim of this study was to investigate the possible associations among the different parts of the uvea in APAC eyes, focusing on the differences in the iris, ciliary body and choroid between APAC and fellow eyes
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