Difference in tolerance development to hypothermia and pentobarbital-induced sleep prolongating effect of 11-hydroxy- Δ8-tetrahydrocannabinol and 11-oxo- Δ8-tetrahydrocannabinol in mice

Abstract

Daily administration (5 mg/kg i.v.) of 11-hydroxy- Δ 8-tetrahydrocannabinol or 11-oxo- Δ 8-tetrahydrocannabinol as well Δ 8-tetrahydrocannabinol quickly induced tolerance to their hypothermic effects in mice. Tolerance also developed to their pentobarbital-induced sleep prolongating effects. However, the degrees of tolerance development differed from one another. The sleeping times after the 8th injection of these cannabinoids were still significantly longer than those of the controls when no hypothermia was induced.