Abstract
Different pathophysiological models provide insight into the important role of CD83+ dendritic cells (DCs) in the pathogenesis of Crohn’s disease (CD) and ulcerative colitis (UC). There were 154 subjects included in this study: 60 with UC, 19 with CD and 75 in the control group. Colonic biopsy was performed in all subjects. Specimens were incubated with a primary anti-CD83 antibody. Intraepithelial DCs per 100 enterocytes were counted. The results were analysed according to demographic data, type of IBD and histological inflammation pattern. The odds ratio for CD83+ DCs=0 in the UC group was 3.4 times higher than that in the control group (OR = 3.4; 95% CI: 1.63–7.14; p = 0.001), and the odds ratio for CD83+ DCs ≥1 in the CD group was 5.3 times higher than that in the UC group (OR = 5.3; 95% CI: 1.4–20.2; p = 0.014). The odds ratio for CD83+ DCs=0 in the acute inflammation group was 2.7 times higher than that in the group without inflammation (OR = 2.7; 95% CI: 1.2–5.9; p = 0.011). In the group of patients with CD and acute inflammation (n = 11), there was only one subject without CD83+ DCs (p = 0,024). These results suggest an association of CD83+ DCs with the type of IBD and the histological inflammation pattern.
Highlights
Inflammatory bowel diseases (IBDs) are chronic inflammatory diseases of the intestines that manifest as either Crohn’s disease (CD) or ulcerative colitis (UC)
After we found an association between the presence of CD83+ dendritic cells (DCs) and the histological inflammation pattern, we found an association between the number of CD83+ DCs and the histological inflammation pattern (p = 0,001) (Table 5)
We found a significant difference in the presence of CD83+ DCs among different types of inflammatory bowel diseases
Summary
Inflammatory bowel diseases (IBDs) are chronic inflammatory diseases of the intestines that manifest as either Crohn’s disease (CD) or ulcerative colitis (UC). DCs are usually situated in areas of the body that make contact with the environment (skin and mucus membranes) and are continuously responding to the environment and recognizing and processing antigens[6,7]. These cells are present in all vascular areas as partially mature DCs, where they recognize self as well as foreign antigens[5]. DCs receive signals from cytokines, intracellular components and lipids in the surrounding area Integration of all these signals determines the cell’s immunologic response, which often results in the transformation of an antigen-recognizing cell into an antigen-presenting cell[5]. The aim of this study was to determine the effect of subject demographic data (age and sex), type of IBD and histological inflammation pattern on the presence and number of mature intraepithelial CD83+ DCs in colonic biopsy samples
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