Abstract

Different sampling technique can impact on post mortem tryptase levels. A previous study demonstrated a significant difference in femoral post mortem total tryptase between blind transcutaneous aspiration and directly sampling during internal examination. The possible reason for this may be due to arterial contamination. This 6-month retrospective study compared 21 paired femoral venous and arterial total post mortem tryptase levels. All cases were non-anaphylactic deaths with a range of natural and unnatural causes of death and presence of resuscitation. Two outliers with higher tryptase were noted in arterial samples. Apart from the outliers, there was no significant difference between the two sample sites, showing a mean difference of 0.89 μg/L (95% CI 1.21–2.99, p=0.11). None of the venous post mortem tryptase levels were above 10 μg/L. This study suggests techniques in minimising arterial blood contamination should be used when sampling for post mortem tryptase.

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