Abstract
Hydrophilic substances are difficult to penetrate into the brain as the blood-brain barrier (BBB) allows only certain substances to penetrate into the brain. However, its permeability is easily changed under various physiological conditions. We previously found that cisplatin, an antitumor platinum (Pt) compound, was penetrated into the mouse brain either by exposure under a short-term hypoxia or injection of lipopolysaccharide (LPS) (Minami et al., 1996a, 1998a). Free radicals, nitric oxide and prostaglandins may be related to induce those phenomena (Minami et al., 1996b, 1998a,b). Although various metals need in the brain, it was reported that a severe mental damage occurred in patients administered cisplatin (Higa et al., 1995). And aluminum (Al) is known as a substance inducing Alzheimer disease (Forbes et al., 1998). The aim of this study is to observe the different penetrations of metals into the brain under injection of LPS.
Published Version
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