Abstract
The effect of prostaglandin (PG) E 1 on the contractile responses of canine separated longitudinal and circular muscles to field stimulation, which produced the release of acetylcholine (ACh), was examined and compared with the effect of verapamil. PGE 1 inhibited the contractile response of circular but not of longitudical muscle to field stimulation. However, it did not affect or only slightly inhibited ACh-induced contraction in both muscles. Verapamil inhibited the contractile responses of both muscles to field stimulation, and it also inhibited ACh-induced contraction in both muscles. These results suggest that PGE 1 mainly acts on the cholinergic nerve terminals of the circular muscle layer, whereas verapamil influences the smooth muscle cells of both muscle layers. The inhibitory effects of PGE 1 and verapamil were partly neutralized by an increase in the external calcium concentration.
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