Difference between remimazolam toluenesulfonic acid and propofol in waking quality and conscious state after general anesthesia.

Abstract

To explore the difference of anesthesia recovery and postoperative conscious state between remimazolam toluenesulfonic acid and propofol after induction and maintenance of general anesthesia. 104 patients undergoing elective tracheal intubation general anesthesia in our hospital were randomly divided into 2 groups: Remimazolam Toluenesulfonic acid group (Group R) and Propofol group (Group P). MOAA/S score, the modified Aldrete score, recovery index, time point, a state of consciousness, interpretative vital signs and adverse events were monitored at different time. Compared with the Group P, the extubation time and orientation recovery time of the Group R were significantly shorter. When the operation time was less than 1 hour, the MOAA/S score of the Group R was shorter than that of Group P at 5min and 15min after the operation. To compare with the Group P, the score of MOAA/S in the Group R increased at 5min, 20min and 30min after the operation. When the operation time was less than or equal to 1h, the modified Aldrete score in the Group R was slightly higher than that in the Group P at 30min after extubation. There was no injection pain in the the Group R, and the incidence of hypotension was lower than that of propofol. Compared with Propofol, when the operation time of general anesthesia is more than 1 hour, recovery time of Remimazolam Toluenesulfonic acid is shorter, with more complete and higher-quality recovery.