Abstract
Differanisole A, 3,5-dichloro-2-hydroxy-4-methoxy-6- n-propylbenzoic acid, inhibited growth of human myeloid leukemia cells. The compound induced G 1 arrest and granulocytic differentiation of HL-60 cells, although the differentiation-inducing effect was modest. Differanisole A and 9- cis retinoic acid (9cisRA) synergistically inhibited the growth and induced functional and morphologic differentiation of HL-60 and NB4 cells, whereas the combined treatment with differanisole A and all- trans retinoic acid or 1 α,25-dihydroxyvitamin D 3 was less effective. Similar results were obtained in primary culture of leukemia cells from a patient with acute promyelocytic leukemia. The synergistic effect on growth inhibition and induction of differentiation required simultaneous treatment with differanisole A and 9cisRA. Differanisole A and an RXR-specific ligand (Ro47-5944) cooperatively inhibited the cell growth, while the combined effect of differanisole A and an RAR-specific ligand Am80 was just additive. Differanisole A in combination with 9cisRA may have implications for therapy of acute promyelocytic leukemia patients.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
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