Abstract
Chlorogenic acids are esters of hydroxycinnamic acids with quinic acid. Coffee is one of the main food sources of chlorogenic acids and during the roasting of the beans, part of these compounds is transformed into lactones or quinides, through the loss of a water molecule and formation of an intramolecular ester bond. Diferuloylquinide (DIFEQ), a representative compound of this class, has previously exhibited hypoglicemic activity in rats, among other biological activities. In the present preliminary study, DIFEQ was diluted in saline and administered to 3 male Sprague Dawley rats through a gastric catheter. Blood draws were taken 20, 40 and 60 min. after DIFEQ administration and plasma samples were analyzed by HPLC‐UV. The main DIFEQ metabolite observed in plasma in all time points was its corresponding chlorogenic acid, diferuloylquinic acid. A series of other metabolites including ferulic acid, isoferulic acid and 3‐feruloylquic acid were also identified, in addition to small amounts of DIFEQ. Whether DIFEQ breakdown occurs prior, during or after absorption is still under investigation. These results suggest that the major compounds responsible for the hypoglycemic and other biological activities of quinides observed in vivo are their corresponding chlorogenic acid compounds and metabolites. Financial support: Institute for Coffee Studies‐VU (USA), CBP&Dcafé (Brazil).
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