Abstract
Diethylene glycol is a chemical that is readily available and has been implicated in multiple mass poisonings when used inappropriately as a diluent in pharmaceutical preparations. Diethylene glycol is an organic compound found in various household products including automotive products and wallpaper stripper. It is two ethylene glycol molecules with a stable ether bond and is metabolized by alcohol dehydrogenase to two known toxic metabolites, 2-hydroxyethoxyacetic acid and diglycolic acid. It causes an anion gap acidosis, cortical necrosis and neurotoxicity. Despite it being very commonly available, many questions remain about its toxicologic fate and mechanism of toxicity.
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