Abstract
Most of the patients with type 2 diabetes mellitus suffer from renal injury. The current study explored the protective effects of dietary zinc against diabetic renal injury and the underlying molecular mechanisms. In experiments, ZnSO4 at 15 mg/kg was intragastrically administrated into type 2 diabetes mellitus-like Wistar rat models daily for continuously 53 days. Biochemical assay was performed to detect serum fasting blood glucose, blood urea nitrogen (BUN), creatinine, and insulin. The H&E staining, immunohistochemical assay, and Western blotting were performed to detect the changes in kidney tissues. In results, dietary zinc reduced the lipid peroxidation malondialdehyde levels and enhanced the total anti-oxidation capacity levels. The pathological changes in diabetic kidney were improved. The percentage of autophagy-associated LC3-II positive cells was lowered. Western blot levels of LC3-II proteins and endoplasmic reticulum (ER) stress-associated GRP78 proteins were lowered. In conclusion, dietary zinc can relieve ER stress and autophagy in diabetic kidney to improve kidney conditions of type 2 diabetes mellitus-like rat models. These findings may be useful to treat patients with diabetic renal injury.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Diabetes in Developing Countries
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
