Abstract
Specific nutrient signals from the intestine may be important drivers of obesity and non-alcoholic fatty liver disease (NAFLD). A common dietary component, wheat amylase trypsin inhibitors (ATI), activate intestinal macrophages and dendritic cells via toll like receptor 4. We showed that upon activation by ATI, these cells migrate and propagate the inflammatory stimulus to the periphery. We therefore studied how far nutritional ATI would affect NAFLD and liver fibrosis in preclinical models of NASH and liver fibrosis.
Published Version
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