Abstract
BackgroundDietary total antioxidant capacity (TAC) has been assumed as a useful tool to assess the relationship between the cumulative antioxidant food capacity and several chronic disorders. The aim of this cross-sectional study was to investigate the potential relationships of dietary TAC with adiposity, metabolic and oxidative stress markers in healthy young adults.MethodsThis study enrolled 266 healthy subjects (105 men/ 161 women; 22 ± 3 years-old; 22.0 ± 2.7 kg/m2). Dietary intake, anthropometry, blood pressure, lifestyle features, and biochemical data were assessed with validated procedures.ResultsIn linear regression analyses, dietary TAC values were inversely associated with glycemia, total cholesterol:HDL-c ratio, triglycerides and oxidized-LDL concentrations, and positively associated with HDL-c concentrations, independently of gender, age, smoking status, physical activity, vitamin use supplement, waist circumference, energy intake, fatty acid intake. In addition, plasma TAC was negatively correlated with ox-LDL concentrations (r= -0.20, P = 0.003), independently of the assessed confounding variables. Finally, dietary TAC values were inversely related to waist circumference values (r= -0.17, P = 0.005) as well as to lower mild central obesity occurrence (waist circumference ≥ 80/ 94 cm for women/ men, respectively).ConclusionDietary TAC values are inversely associated with glucose and lipid biomarkers as well as with central adiposity measurements in healthy young adults, indicating dietary TAC as a useful tool to assess the health benefits of cumulative antioxidant capacity from food intake. In addition, the independent and inverse relationships of ox-LDL concentrations with dietary and plasma TAC respectively suggest a putative role of antioxidant rich-diet in the link between redox state and atherogenesis at early stage.
Highlights
Dietary total antioxidant capacity (TAC) has been assumed as a useful tool to assess the relationship between the cumulative antioxidant food capacity and several chronic disorders
Those participants who were included in the third tertile of dietary TAC presented higher consumption of olive oil, fruits, vegetables, fruit juices, fish, coffee and red wine as well as higher intake values of protein, lipids, monounsaturated fatty acid (MUFA), and dietary fiber, while lower intake values for saturated fatty acid (SFA) were found as compared with subjects in the lowest tertile (Table 2)
Regarding the association between dietary TAC and glucose profile, dietary TAC values were inversely associated with glycemia and HOMA-IR (P < 0.05), independently of gender, age, waist circumference, smoking habit, physical activity counts, vitamin supplement use (Table 3)
Summary
Dietary total antioxidant capacity (TAC) has been assumed as a useful tool to assess the relationship between the cumulative antioxidant food capacity and several chronic disorders The aim of this cross-sectional study was to investigate the potential relationships of dietary TAC with adiposity, metabolic and oxidative stress markers in healthy young adults. Despite some authors have debated about the applicability of the extrapolation of dietary TAC data to its antioxidant contribution in vivo [8,9], this dietary index has been a relevant tool in epidemiological studies [10,11] In this sense, increased dietary TAC has been associated with higher diet quality scores [12] as well as with improved values concerning glucose metabolism [13] and inflammatory status [14,15] in middle-aged people. The association between this dietary TAC and ox-LDL concentrations has not been apparently reported
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