Dietary total antioxidant capacity as a preventive factor against depression in climacteric women.

Natiani Gonçalves De Oliveira,Catia Santos Branco,Heloísa Theodoro,Iranice Taís Teixeira

doi:10.1590/1980-57642018dn13-030007

Natiani Gonçalves De Oliveira, Catia Santos Branco + Show 2 more

Open Access

https://doi.org/10.1590/1980-57642018dn13-030007

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Journal: Dementia & Neuropsychologia	Publication Date: Jan 1, 2019
Citations: 19	License type: CC BY 4.0

Affiliation: Universidade de Caxias do Sul

Abstract

ABSTRACTDepression is characterized by physical or psychological distress and in many cases can lead to suicide.Objective:to assess the prevalence of depression and its possible relationship with dietary total antioxidant capacity (DTAC) and nutritional parameters in climacteric women participating in an extension university program in a Southern Brazilian city.Methods:data were obtained through questionnaires and anthropometric measurements. Diet was assessed using a 24-hour dietary recall. The Beck Depression Inventory (BDI) was used to assess the intensity of symptoms of depression.Results:DTAC of the population ranged from 435.60 to 4502.62 mg VCE/day. Among the most consumed antioxidant food/beverages, coffee ranked highest. Polyphenols were found to be directly linked to the antioxidant capacity of fresh foods (r=0.905; p=0.0001). Prevalence of depression in the population was 44%, and depressed women had lower intake levels of polyphenols (p=0.022; Cohen's d=0.80), and vitamin B6 (p=0.038; Cohen's d=0.65), vitamin A (p=0.044; Cohen's d =0.63), and vitamin C (p=0.050; Cohen's d =0.61). There was a significant negative correlation between BDI scores and polyphenol intake (r=-0.700; p=0.002).Conclusion:these results may contribute to a better understanding of the recommended dietary antioxidant intake as an adjuvant for preventing depression in women.

Highlights

Depression is characterized by physical or psychological distress and in many cases can lead to suicide
Depression is characterized by distress, either physical or psychological; resulting from a complex interaction of social, psychological and biological factors, and in many cases can lead to suicide.[1,2]
For calculation of dietary total antioxidant capacity (DTAC), women were instructed to recall all known antioxidant foods consumed during the previous day

Summary

Introduction

Depression is characterized by physical or psychological distress and in many cases can lead to suicide. Regarding the disease’s prevalence, women are the most affected, with two female cases diagnosed for every male case.[3] One of the reasons that lead women to experience depression is hormonal change, in which the climacteric period is important.[4,5,6] Changes in estrogen secretion modify the levels of noradrenaline and serotonin in the brain.[7] the classic symptoms of depression, such as irritability, melancholy, mood and emotional lability, manifest.[5] Apart from hypoestrogenism, other factors can contribute to the development of depression in women One of these factors is the nutrient deficiency that occurs throughout life, especially with respect to some amino acids, vitamins and minerals.[8,9,10,11] it has been demonstrated that depression is linked to a decrease in circulating antioxidants.[12,13,14,15]. These micronutrients are secondary plant metabolites that exhibit a broad spectrum of pharmacological activities, including neuroprotection[17,18] and antidepressant action.[19,20] Previous evidence shows that antioxidants present in foods from natural sources can influence brain dynamics and functioning through a preventive and/or therapeutic effect elicited by these compounds.[10,13,21,22]

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Results