Dietary total antioxidant capacity and prostate cancer tumor stage among African and Caucasian Americans in a population‐based study

Abstract

Data from the North Carolina‐Louisiana Prostate Cancer Project, a population‐based study of incident prostate cancer in African Americans (AA) (n=698) and Caucasian Americans (CA) (n=904), were used to determine the association between dietary total antioxidant capacity (TAC) and prostate cancer tumor stage at diagnosis. Dietary data were collected using a modified NCI DHQ. The DHQ food and nutrient database was modified to include data on flavanoids and proanthocyanidins. Dietary TAC was calculated from the vitamin C equivalent antioxidant capacity of 42 dietary antioxidants. Associations between dietary TAC and tumor stage were determined by logistic regression. The odds ratio for tumor stage 2 (ref: tumor stage 1) was 0.61 (95% CI: 0.40, 0.92, p‐trend= 0.016) for CA and 0.68 (95% CI: 0.50, 0.92, p‐trend=0.015) for all men in the highest quartile of dietary TAC. A similar trend was found for tumor stages 3 and 4 (p‐trend=0.051 for CA and 0.067 for all men, respectively). In this study of prostate cancer in AA and CA, greater dietary TAC was found to be associated with decreased risk of greater tumor stage.Grant Funding Source: NIH Cancer Epidemiology Small Grant #1R03CA159421–01A1.