Abstract
Ageing is associated with several anatomical and physiological changes of the organism, and the increase in global elderly population promotes the research to develop strategies to improve their quality of life. In this work, we characterized the immunological alterations naturally produced during aging in a mice model, and evaluated the effect of probiotic Lactobacillus (L.) rhamnosus CRL1505 administration on those immunological parameters. We demonstrated that L. rhamosus CRL1505 was able to improve peritoneal macrophages phagocytic activity, and the number of intestinal IgA+ cells in aged mice, reaching values of those parameters similar to young adult mice. The results of this work indicate that is plausible that the immunobiotic CRL1505 strain may find applications as a beneficial immunomodulator in aging to reinforce the intestinal and systemic immunity. The immune modulation in aging induced by L. rhamnosus CRL1505 could lead to the development of new strategies for functional foods specifically tailored for the elderly.
Highlights
Aging is a manifold of universal biological processes that profoundly alter anatomy and physiology of all organisms
We have previously reported that Lactobacillus (L.) rhamnosus CRL1505, strain isolated from goat milk, has probiotic properties
Mice were randomly allocated to four main experimental groups as follows: EBc group (Elderly Basal control group) elderly mice that received water ad libitum; EM group (Elderly Milk group) elderly mice that received reconstituted skim milk (RSM) ad libitum; E-1505 group (Elderly + 1505 group) elderly mice that received L. rhamnosus CRL1505; YB group (Young Basal) young mice that received water ad libitum
Summary
Aging is a manifold of universal biological processes that profoundly alter anatomy and physiology of all organisms. Studies in mice models show that administration of CRL1505 strain enhances the resistance against intestinal and respiratory pathogens in infant and young adult mice, improving both systemic and mucosal immune responses [6] [7]. These effects were related to the capacity of L. rhamnosus CRL1505 to beneficially regulate the balance between inflammatory and regulatory cytokines, improve phagocytes activity, and enhance systemic and mucosal humoral immune responses [6]. This study is undertaken to find out whether the immunobiotic L. rhamnosus CRL1505 exerts beneficial effects in aged hosts
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