Abstract
To study whether balance between antiaggregatory, vasodilatory prostacyclin (PGI 2) and proaggregatory, vasoconstrictory thromboxane A 2 (TXA 2) could be affected by dietary manipulation, 18 pre-eclamptic women were treated in randomized order between 31 and 36 weeks of gestation either with primrose oil (n =7), with fish oil (n =5), or with placebo (n = 6). Urinary excretions of the degradation products of PGI 2 (6-keto-PGF 1α, 2,3-dinor-6-keto-PGF 1α) and TXA 2 (TXB 2, 2,3-dinor-TXB 2) were measured in 24 h urines before and serially during the supplementation. Fatty acid supplementation did not affect urinary prostanoid excretions or clinical signs of pre-eclampsia.
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