Dietary Supplementation with Pioglitazone Hydrochloride and Resveratrol Improves Meat Quality and Antioxidant Capacity of Broiler Chickens

Fan Zhang,Chunqi Gao,Huize Tan,Huichao Yan,Chenglong Jin,Shiguang Jiang,Xiuqi Wang

doi:10.3390/app10072452

Fan Zhang, Chunqi Gao + Show 5 more

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https://doi.org/10.3390/app10072452

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Abstract

The study aimed to investigate the effects of pioglitazone hydrochloride (PGZ) and resveratrol (RES) on yellow-feathered broiler chickens. A total of 500 broiler chickens were randomly divided into four groups and fed a basic diet (control group) or a basic diet supplemented with 15 mg/kg PGZ, 400 mg/kg RES, or 15 mg/kg PGZ plus 400 mg/kg RES for 28 days. Compared with the control group, the PGZ and PGZ plus RES groups presented a significantly higher average daily gain and a decreased feed-to-gain ratio. Increases in the dressing percentage, semi-eviscerated yield, muscle intramuscular fat content, and C18:1n-9c, C18:3n-6, C20:3n-3, and monounsaturated fatty acid (MUFA) percentages were found in the PGZ plus RES group. Moreover, the diet supplemented with RES or PGZ plus RES increased the activities of catalase, glutathione peroxidase, and superoxide dismutase, and decreased the levels of reactive oxygen species of thigh muscle. Additionally, the mRNA abundance of peroxisome proliferator-activated receptor γ coactivator 1α, fatty acid-binding protein 3, nuclear factor erythroid-2-related factor 2, and superoxide dismutase 1 was increased in the PGZ plus RES group. In conclusion, this study suggested that dietary supplementation of PGZ combined with RES improved the growth performance, the muscle intramuscular fat content, and antioxidant ability of yellow-feathered broiler chickens.

Highlights

In recent years, the demands of consumers have shifted from quantity to quality and, as a result, the intramuscular fat (IMF) content and fatty acid profile of poultry meat have become important to both producers and consumers [1]
After feeding for 28 days, the broiler chickens belonging to the pioglitazone hydrochloride (PGZ) and PGZ + RES groups presented heavier weights compared to the control group (p < 0.05)
Our results show that the PGZ and PGZ + RES groups present decreased CHO and low-density lipoprotein cholesterol (LDL-C) levels but increased high-density lipoprotein cholesterol (HDL-C) concentrations, indicating that these broiler chickens exhibit an increased lipid utilization and an improved fat metabolism in vivo, which is more beneficial for IMF deposition rather than shifting toward abdominal fat [22,38,39]

Summary

Introduction

The demands of consumers have shifted from quantity to quality and, as a result, the intramuscular fat (IMF) content and fatty acid profile of poultry meat have become important to both producers and consumers [1]. Unsaturated fatty acids are susceptible to oxidation, and malonaldehyde (MDA) is well known as one of the end products of this process [3]. Lipid oxidation is one of the main factors leading to the deterioration of meat quality, which can occur both before and after death [4]. Lipid oxidation causes adverse changes in glycolysis that increase the drip loss and thereby lead to meat spoilage and a shorter shelf life [5,6]. An effective approach for improving the IMF and protecting intramuscular lipids against oxidative damage is needed

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