Year-end Sale % OFF 
Abstract
Atherosclerosis is a pathological process, where recruitment of mononuclear cells results in the growth of fibro-fatty plaques. Apolipoprotein E (ApoE) is a legend for the uptake of lipoproteins, and deficiency of ApoE leads to the accumulation of low-density lipoprotein. Utilizing ApoE-/- mouse, which spontaneously develop atherosclerosis on low-fat chow diets, the present study showed that feeding these mice on a diet supplemented with the whole tubers of Cyperus esculentus L (tiger nut) resulted in attenuation of the development of atherosclerotic lesions. The anti-atherosclerotic effect was associated with a decrease in the number of monocytes, macrophages and dendritic cells in blood, and the expression of IL-2Rα and LFA-1 by these cells. Further, in vitro proliferation of blood and spleen cells from tiger nut-fed ApoE-/- mice showed lower proliferation in responses to ConA and LPS, a T and B cell mitogen, respectively. Further, in vitro treatment of blood and spleen cells with water or ethanol extracts of tiger nut markedly increased their proliferation in response to ConA. Collectively, these data indicate that ingredients of tiger nut tubers exhibit anti-inflammatory properties upon inflammation, and immunostimulatory effects in immunocompetent hosts.
Highlights
Atherosclerosis is a pathological process, which gives rise to fatty streak lesions within arteries that are foci of macrophage (Μφ)-derived foam cells trapped beneath the endothelial-cell lining of the artery [1]
FEEDING TIGER NUT DIMINISHED THE ATHEROSCLEROTIC LESIONS IN APOE-/MICE: Apolipoprotein E (ApoE)-/- mice were fed for 11 weeks on control or the experimental diet, sacrificed and the aorta was perfused with PBS via a cannula inserted in the right ventricle, the heart was dissected, and the crosssectional lesion volume was determined to quantify the atherosclerotic lesion of the aortic root
FEEDING TIGER NUT DECREASES FREQUENCY OF INFLAMMATORY CELLS IN Peripheral blood lymphocytes (PBLs): Because development of atherosclerotic lesions in ApoE-/- mice is mediated by accumulation of inflammatory cells into the inflammatory lesions in blood, we analyzed the number and phenotype of these cells in the peripheral pool
Summary
Atherosclerosis is a pathological process, which gives rise to fatty streak lesions within arteries that are foci of macrophage (Μφ)-derived foam cells trapped beneath the endothelial-cell lining of the artery [1]. Recent studies highlighted the role of inflammatory mediators and the cells of the innate and adaptive immune response in the initiation, growth and rupture of atherosclerotic plaques [2] Viewing this form of vascular pathology as a modified form of chronic inflammation suggests new avenues for therapeutic interventions in atherosclerosis and cardiovascular diseases [2]. In Spain the tubers are consumed mainly as a drink called locally “horchata de chufa” (chufa milk) This plant was originally native to the Mediterranean region but its cultivation has spread to many other warm countries [14]. CONTROL AND EXPERIMENTAL DIETS: ApoE/- mice were fed AIN-93G [17] diet supplemented with provide a new avenue for the natural remedy-based 25 % whole powder of chufa tubers (experimental diet) treatment of inflammatory diseases, such as or without (control diet) for 11 weeks. CD40 FITC, anti-CD40L FITC, anti-CD62L-PE, antiCD69 PE and anti-B220-FITC were purchased from Pharmingen (San Diego, CA)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
