Abstract
ObjectiveOxidative stress and mitochondrial dysfunction mediated neuronal apoptosis is reported to play a major role in the pathology of Parkinson's disease. Walnuts are able to offer protection to neurodegenerative disease models and rich in natural antioxidants. In the present study, we investigated the protective effects of walnut extract against 1‐methyl‐4‐phenylpyridinium (MPP+) induced neurotoxicity in SH‐SY‐5Y cell lines.MethodsThe effect of Walnut extract on MPP+ induced cell viability (MTT ‐ 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazoliumbromide assay), membrane damage ‐(lactate dehydrogenase (LDH), oxidative stress (levels of ROS, nitric oxide and GSH and activities of SOD and catalase), mitochondrial membrane potential and apoptosis (activity of caspase 3 and protein expressions of cyt. c, Bax and Bcl‐2) were measured.ResultsOur results showed that walnuts extract could be able to reduce the neurotoxicity of MPP+ and offer neuroprotection in vitro.ConclusionThis protective effect of walnuts might be mediated by its potent antioxidant properties. However, further research is necessary to isolate active compounds and performing preclinical and clinical studies to confirm the neuroprotective effects of walnuts in PD.Support or Funding InformationThe support provided by Internal grant from CAMS, Sultan Qaboos University (IG/AGR/FOOD/14/01) is highly acknowledged.
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