Dietary supplemental vitamin B6 increases carnosine and anserine concentrations in the heart of rats

Sofya Suidasari,Noriyuki Yanaka,Tomoko Hasegawa,Norihisa Kato

doi:10.1186/s40064-015-1074-8

Abstract

This study was performed to examine the effect of dietary level of vitamin B6 on the concentrations of carnosine and anserine, antioxidants, in the heart of rats. Analysis using UPLC–MS/MS showed that the concentrations of these dipeptides in the 7 and 35 mg pyridoxine HCl/kg groups were significantly higher than those in the 1 mg pyridoxine HCl/kg group, implying the novel role of dietary vitamin B6 as a determinant of the dipeptides favorable for heart.

Highlights

Increasing evidence indicates that lower levels of vitamin B6 (B6) are related to the risk of coronary heart disease and atherosclerosis (Robinson et al 1998), with the antiinflammatory effect of B6 considered to be at least partially responsible for its protective effect against these diseases (Friso et al 2004)
We hypothesized that dietary supplemental B6 affects heart dysfunction by modulating amino acid metabolism
We provide the first evidence that dietary supplemental B6 to a low B6 diet markedly elevates heart concentrations of carnosine and anserine, putative antioxidants favorable for heart (Boldyrev et al 2013)

Summary

Introduction

Increasing evidence indicates that lower levels of vitamin B6 (B6) are related to the risk of coronary heart disease and atherosclerosis (Robinson et al 1998), with the antiinflammatory effect of B6 considered to be at least partially responsible for its protective effect against these diseases (Friso et al 2004). The effect of B6 on the heart per se remains obscure. We hypothesized that dietary supplemental B6 affects heart dysfunction by modulating amino acid metabolism. We investigated the effects of low to high B6 diets on the concentrations of free amino acids and related metabolites in the heart of rats. We provide the first evidence that dietary supplemental B6 to a low B6 diet markedly elevates heart concentrations of carnosine and anserine, putative antioxidants favorable for heart (Boldyrev et al 2013)

Methods

Results

Conclusion