Abstract
Randomized controlled trials showed that soy intervention significantly improved blood lipids in people with diabetes. We sought to prospectively examine the association of soy consumption with the risk of cardiovascular death among individuals with diabetes. A total of 26,139 participants with a history of diabetes were selected from the Chinese Kadoorie Biobank study. Soy food consumption was assessed by a food frequency questionnaire. Causes of death were coded by the 10th International Classification of Diseases. The Cox proportional hazard regression was used to compute the hazard ratios. During a median follow-up of 7.8 years, a total of 1626 deaths from cardiovascular disease (CVD) were recorded. Compared with individuals who never consumed soy foods, the multivariable-adjusted risks (95% confidence intervals) of CVD mortality were 0.92 (0.78, 1.09), 0.89 (0.75, 1.05), and 0.77 (0.62, 0.96) for those who consumed soy foods monthly, 1–3 days/week, and ≥4 days/week, respectively. For cause-specific cardiovascular mortality, significant inverse associations were observed for coronary heart disease and acute myocardial infarction. Higher soy food consumption was associated with a lower risk of cardiovascular death, especially death from coronary heart disease and acute myocardial infarction, in Chinese adults with diabetes.
Highlights
Accepted: 20 July 2021Soy is rich in plant protein, soy isoflavones, vitamins, dietary fiber, and minerals [1].Numerous randomized controlled trials (RCTs) have examined the effects of soy intervention on cardiovascular risk factors
To fill this knowledge gap, in the current analysis, we aimed to examine whether soy consumption is associated with cardiovascular disease (CVD) mortality among individuals with type 2 diabetes in the Chinese
The present cohort study provided evidence that higher consumption of soy products was inversely associated with risk of mortality due to CVD, especially coroheart disease (CHD) and acute myocardial infarction, in people with type 2 diabetes
Summary
Accepted: 20 July 2021Soy is rich in plant protein, soy isoflavones, vitamins, dietary fiber, and minerals [1].Numerous randomized controlled trials (RCTs) have examined the effects of soy intervention on cardiovascular risk factors. Clinical trials have shown that soy intervention significantly improved blood lipids in people with type 2 diabetes, blood glucose, insulin, and glycated hemoglobin were not affected [7]. Evidence regarding the association between soy and CVD incidence or mortality in people with type 2 diabetes is sparse, with only one Singapore study on this topic [9]. To fill this knowledge gap, in the current analysis, we aimed to examine whether soy consumption is associated with CVD mortality among individuals with type 2 diabetes in the Chinese
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