Abstract
The current study aims to investigate the effects of dietary source of n-3 polyunsaturated fatty acids (PUFA) on immune response in broiler chickens, represented by cytotoxic cell activity. A total of 255 one-day-old male Cobb 500 broiler chickens were fed on fish oil (FO)-, flaxseed oil-enriched diets at 50 and 19 g/kg, respectively, in addition to the soybean-based control diet. At slaughter, samples of blood and spleen were harvested from 20 birds/treatment (n = 20). The immune tissues' fatty acid profile was analyzed by gas chromatography, and the cytotoxic cell activity was investigated. The results showed that supplementing broiler chickens with diets rich in n-3 PUFA had a substantial effect on the broiler immune tissues' fatty acid profile. Cytotoxic cell activity was significantly higher in splenocytes and peripheral blood mononuclear cells (PBMCs) from broilers fed flaxseed oil than those provided FO and the soybean control diet. These results suggest that flaxseed oil may be used to enrich chickens with n-3 PUFA and improve the immune status of chicken flocks to resist diseases.
Highlights
The current study aims to investigate the effects of dietary source of n-3 polyunsaturated fatty acids (PUFA) on immune response in broiler chickens, represented by cytotoxic cell activity
The results showed that using supplementary flaxseed oil in broiler chickens significantly enhanced cytotoxic cell activity of splenocytes, while fish oil (FO) resulted in the lowest cytotoxic cell activity (Fig. 1)
The current study investigated the effect of using flaxseed and FO in the feed ration, production performance parameters, cytotoxic cell activity of splenocytes, and peripheral blood mononuclear cells (PBMCs) of broiler chickens
Summary
The current study aims to investigate the effects of dietary source of n-3 polyunsaturated fatty acids (PUFA) on immune response in broiler chickens, represented by cytotoxic cell activity. Cytotoxic cell activity was significantly higher in splenocytes and peripheral blood mononuclear cells (PBMCs) from broilers fed flaxseed oil than those provided FO and the soybean control diet. These results suggest that flaxseed oil may be used to enrich chickens with n-3 PUFA and improve the immune status of chicken flocks to resist diseases. This research aimed to explore the influence of feeding broiler chickens on diets rich in fish oil (FO) or flaxseed oil on cytotoxic cell activity in splenocytes and PBMCs of 5 wks old broiler chickens. Fish oil is a rich source of EPA and DHA, which are precursors of lipid
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