Abstract
Sensitization to parathyroid hormone by the oral administration of calcium acetate, sodium phosphate, and corn oil was studied comparatively in the rat. Calcium acetate greatly faciliates the induction by parathyroid extract of calcification in the cardiovascular system, skeletal musculature, and renal cortex, as well as the production of osteitis fibrosa, particularly if, at the same time, the intake of fat is augmented. Sodium phosphate likewise increases the activity of parathyroid hormone, though in equimolecular amounts this salt is less effective than calcium acetate; moreover, sodium phosphate—unlike calcium acetate—changes the quality of the resulting morbid lesions in that the cardiac calcification is accompanied by suppuration, and the nephrocalcinosis shifts to the corticomedullary junction. The effects of combined treatment with parathyroid hormone and sodium phosphate are likewise aggravated by orally administered fat-supplements. Attention is called to the fact that the same sensitizing agen...
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