Abstract
Cholesterol is obtained through biosynthesis and diet. When a level of cholesterol is above the normal level, this condition caused hypercholesterolemia. Long-term administration of synthetic chemical drugs can cause liver damage. Therefore, alternative natural medication is needed. One of the alternatives that can be used is the rice bran (RB), which contains antioxidant and crude fiber. This study is aimed at finding out the potential utilization of RB on total cholesterol level, liver enzyme as aspartate aminotransferase (AST) and alanine aminotransferase (ALT), malondialdehyde (MDA), and the changes in liver tissue. This study uses five groups of rats: the negative control group, positive control group, and three therapy groups with the dosage of 270 mg kg -1 , 540 mg kg -1 , and 810 mg kg -1 of body weight. This study shows that therapy using RB can significantly decrease the cholesterol level, AST, ALT, and MDA (p<0.01). The total cholesterol level is 21%, AST and ALT activities can be reduced to 54% and 64%, the level of MDA reduced to 79% and can repair the liver tissue. This study shows that RB can be effectively used as hepatoprotective in rats with hypercholesterolemia. Keywords: AST and ALT, Hypercholesterolemia, Rice Bran, Total Cholesterol Level.
Highlights
Hypercholesterolemia is influenced by age, sex, alcohol, obesity, stress, diabetes, and food intake [1,2,3]
Hypercholesterolemia can become the risk for atherosclerosis, pancreatitis, coronary heart, thyroid disorder, kidney failure, and liver damage [4]
The increase of free radical can reduce the activity lipoprotein lipase enzyme (LPL). This can cause a disturbance in the changes of very low-density lipoprotein (VLDL) into intermediate density lipoprotein (IDL)
Summary
Hypercholesterolemia is influenced by age, sex, alcohol, obesity, stress, diabetes, and food intake [1,2,3]. The increase of free radical can reduce the activity lipoprotein lipase enzyme (LPL). This can cause a disturbance in the changes of very low-density lipoprotein (VLDL) into intermediate density lipoprotein (IDL). Long-term medication of hypercholesterolemia using synthetic chemical medicine can cause liver damage and kidney functions disorder [12]. Dietary Rice Bran in the Hepatoprotective Effect (Antula et al) cholesterol level, this study is carried out to find the role of RB as hepatoprotective in rats with hypercholesterolemia, by using the liver function parameters of activity of the AST and ALT enzymes, MDA in liver organ, and supported by the observation of the liver tissue. This study will examine the effect of RB on total cholesterol levels, liver enzymes activity (AST and ALT), and MDA levels
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
