Abstract
Inflammatory bowel diseases (IBD), after disease onset, typically progress in two cyclically repeated phases, namely inflammatory flare and remission, with possible nutritional status impairment. Some evidence, either from epidemiological, clinical, and experimental studies indicate that the quantity and the quality of dietary protein consumption and amino acid supplementation may differently influence the IBD course according to the disease phases. For instance, although the dietary protein needs for mucosal healing after an inflammatory episode remain undetermined, there is evidence that amino acids derived from dietary proteins display beneficial effects on this process, serving as building blocks for macromolecule synthesis in the wounded mucosal area, energy substrates, and/or precursors of bioactive metabolites. However, an excessive amount of dietary proteins may result in an increased intestinal production of potentially deleterious bacterial metabolites. This could possibly affect epithelial repair as several of these bacterial metabolites are known to inhibit colonic epithelial cell respiration, cell proliferation, and/or to affect barrier function. In this review, we present the available evidence about the impact of the amount of dietary proteins and supplementary amino acids on IBD onset and progression, with a focus on the effects reported in the colon.
Highlights
After disease onset, the alternation of inflammation and remission episodes characterizes the progression of inflammatory bowel diseases (IBD)
The use of dietary proteins and amino acid (AA) supplementation to control inflammation and promote mucosal healing (MH), being suggested in experimental models, awaits further human studies in order to establish its possible interest in clinical practice
Epidemiological evidence indicates that the consumption of a diet with high animal protein content is associated with an increased risk of Inflammatory bowel diseases (IBD), the mechanisms which would explain such an association remain elusive
Summary
The alternation of inflammation and remission episodes characterizes the progression of inflammatory bowel diseases (IBD). Malnutrition is more allow healing, the optimal dietary composition in terms of macronutrients, vitamins, and minerals, frequently observed in CD of patients because the small bowelmucosa may be causing nutrient as well as the impact these compounds on the intestinal areaffected, still largely unknown. It is malabsorption and possible nutritional deficiencies [7],differ in contrast affects worth noting that the nutritional impact of diet may between to CDUC, andwhich.
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