Abstract
This study aimed to test the association between dietary content of total and individual classes of polyphenols and incident cases of type 2 diabetes in Polish adults participating to the Health, Alcohol and Psychosocial factors In Eastern Europe study. At baseline, diet by 148-item FFQ and health information were collected from 5806 participants free of diabetes. Self-reported incident type 2 diabetes was ascertained at 2-4-year follow-up visit. OR and 95 % CI of type 2 diabetes comparing the various categories of polyphenol intake to the lowest one (reference category) and as 1 sd increase modelled as continuous variable were calculated by performing age-, energy-, and multivariate-adjusted logistic regression models. During the follow-up, 456 incident cases of type 2 diabetes occurred. When comparing extreme quartiles, intake of total polyphenol was inversely associated with the risk of type 2 diabetes (OR 0·43; 95 % CI 0·30, 0·61); 1 sd increase was associated with a reduced risk of diabetes (OR 0·68; 95 % CI 0·59, 0·79). Among the main classes of polyphenols, flavonoids, phenolic acids, and stilbenes were independent contributors to this association. Both subclasses of phenolic acids were associated with decreased risk of type 2 diabetes, whereas among subclasses of flavonoids, high intake of flavanols, flavanones, flavones and anthocyanins was significantly associated with decreased risk of type 2 diabetes. Total dietary polyphenols and some classes of dietary polyphenols were associated with lower risk of type 2 diabetes.
Highlights
Plant-derived dietary pattern have been suggested to exert protection against metabolic disorders, such as type 2 diabetes[1]
We aimed to test the association between dietary content of total and individual classes of polyphenols and self-reported incident cases of type 2 diabetes in Polish adults participating to the Health, Alcohol and Psychosocial factors in Eastern Europe (HAPIEE) study
In this study we observed that individuals with higher total dietary polyphenol intake were less likely to develop type 2 diabetes compared with those in the lowest quartile of intake
Summary
Plant-derived dietary pattern have been suggested to exert protection against metabolic disorders, such as type 2 diabetes[1]. Among the most attractive hypotheses potentially explaining the benefits associated with high consumption of fruits and vegetables, polyphenols content is one of the best candidates as determinant of health. Polyphenolic compounds are molecules highly contained in the aforementioned food and plant-derived beverages divided into four main classes on the basis of their chemical structure, including flavonoids, phenolic acids, stilbenes, and lignans, and ‘other’ polyphenols including various type of compounds[3]. We aimed to test the association between dietary content of total and individual classes of polyphenols and self-reported incident cases of type 2 diabetes in Polish adults participating to the Health, Alcohol and Psychosocial factors in Eastern Europe (HAPIEE) study
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