Abstract
Niacin deficiency has been documented in alcoholic liver disease. The present study was undertaken to determine whether dietary supplementation with niacin provides beneficial effects on ethanol‐induced liver injury. Male Sprague Dawley rats were pair‐fed the Lieber‐DeCarli liquid ethanol or isocaloric control diet for 8 weeks with or without niacin supplementation to ethanol‐fed rats at 200 mg/kg BW. Chronic ethanol feeding upregulated hepatic mRNA levels CD14, LBP, CINC‐1 and MCP‐1 and cause liver damage, which were attenuated by niacin supplementation. Niacin supplementation also normalized ethanol‐increased plasma endotoxin level. Ethanol feeding remarkably decreased the intestinal mRNA levels of tight junction proteins including claudin‐1, claudin‐5 and ZO‐1, while niacin supplementation dramatically increased the mRNA levels of these tight junction proteins. Ethanol feeding increased intestinal acetaldehyde concentration, which was attenuated by niacin. These results demonstrated that attenuation of gut leakiness and endotoxin signaling in the liver contributes to the protective effects of niacin against alcoholic liver damage.
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