Abstract
The use of n-3 polyunsaturated fatty acids (n-3PUFA) in preventive or therapeutic modalities for postpartum depression, especially long-chain types such as eicosapentaenoic acid (EPA) and a docosahexaenoic acid (DHA), is of considerable interest. High n-3PUFA consumption has been reported among pregnant Japanese women. Therefore, analysis of this group could provide important insights into the relationship between postpartum depression and dietary n-3PUFA consumption. To further examine the relationship between the risk of postpartum depression and n-3PUFA consumption, we conducted a prospective hospital-based birth cohort study in Japan. Our prospective birth cohort study was performed at the National Center for Child Health and Development (NCCHD) in suburban Tokyo, Japan. Dietary n-3PUFA intake during late pregnancy was assessed by a semi-quantitative food questionnaire and participants were categorized by quintile distributions of n-3PUFA intake. A Japanese translation of the Edinburgh Postnatal Depression Scale was used to screen women for postpartum depression at 1 month after delivery (967 women) and at 6 months after delivery (710 women). We performed logistic regression analysis to examine the relationship between the risk of postpartum depression and n-3PUFA consumption after adjusting for confounding factors. Significant associations between EPA, DHA, and n-3PUFA intakes in late pregnancy and postpartum depression at both 1 and 6 months after delivery were not observed. This prospective study indicated that EPA, DHA, and n-3PUFA intake during late pregnancy was not associated with the risk of postpartum depression.
Highlights
Postpartum depression is one of the most common psychopathologies with a reported prevalence between 10 and 15% [1]
Considerable interest has been shown in the potentiality of n-3 polyunsaturated fatty acids (n-3PUFA), especially long-chain ones such as an eicosapentaenoic acid (EPA) and a docosahexaenoic acid (DHA), to prevent depression [3,4,5,6,7,8,9,10,11]
Our study found that EPA and DHA intakes during late pregnancy did not significantly reduce the risk of postpartum depression both at 1 month after delivery and at 6 months after delivery among postpartum Japanese women, whose average dietary fish intake was higher than those of women in other countries [33, 34]
Summary
Postpartum depression is one of the most common psychopathologies with a reported prevalence between 10 and 15% [1]. Considerable interest has been shown in the potentiality of n-3 polyunsaturated fatty acids (n-3PUFA), especially long-chain ones such as an eicosapentaenoic acid (EPA) and a docosahexaenoic acid (DHA), to prevent depression [3,4,5,6,7,8,9,10,11]. The use of n-3 polyunsaturated fatty acids (n-3PUFA) in preventive or therapeutic modalities for postpartum depression, especially long-chain types such as eicosapentaenoic acid (EPA) and a docosahexaenoic acid (DHA), is of considerable interest. To further examine the relationship between the risk of postpartum depression and n-3PUFA consumption, we conducted a prospective hospital-based birth cohort study in Japan
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