Dietary Magnesium Intake and Risk of Type 2 Diabetes Mellitus Using Data from the HEALTHY Study

Abstract

Abstract Objectives Type 2 diabetes mellitus (T2DM) in children and adolescents has increased dramatically worldwide. Diet plays a key role in the development of T2DM, but little is known about the contribution of dietary magnesium intake in the risk of T2DM among children and adolescents. We conducted secondary analyses using the HEALTHY Study data. The HEALTHY Study was a multi-component, school-based intervention designed to reduce modifiable risk factors for T2DM in middle school students from 6th through 8th grades. The purpose of our study was to examine whether the difference in dietary magnesium intake, body mass index (BMI) percentile, and plasma glucose and insulin concentrations from 6th to 8th grade were related in the intervention schools and in the control schools that participated in the HEALTHY Study. Methods A total of 2181 students from intervention and control schools with completed dietary records, BMI percentile, plasma glucose and insulin concentrations, at 6th and 8th grades were included in these analyses. Dietary magnesium intake was self-reported using the Block Kids Food Frequency Questionnaire. A hierarchical multiple regression model was used to determine whether the difference in dietary magnesium intake, BMI percentile, and plasma glucose and plasma insulin concentrations from 6th to 8th grades were related, while adjusting for dietary calcium intake. Results The difference in dietary magnesium intake was a significant predictor for changes in BMI percentile in control schools from 6th to 8th grade (β = −0.07, 95% confidence interval [CI] = −0.03 to −0.01, P = 0.007; R2 [regression coefficient effect size] = 0.24, 95% CI for R2 = 0.19 to 0.28) indicating a small-to-medium effect size. Conclusions We concluded that changes in dietary magnesium intake from 6th to 8th grades were negatively related to changes in BMI percentile among middle school students. Funding Sources The original research related to this abstract was funded by the National Institute of Diabetes and Digestive and Kidney Disease (NIDDK) of the National Institutes of Health (NIH), with additional support from the American Diabetes Association.