Dietary Lutein Plus Zeaxanthin Intake and DICER1 rs3742330 A\u2009>\u2009G Polymorphism Relative to Colorectal Cancer Risk

Jimi Kim,Jeonghee Lee,Jae Hwan Oh,Oran Kwon,Jeongseon Kim,Dae Kyung Sohn,Hee Jin Chang,Aesun Shin

doi:10.1038/s41598-019-39747-5

Jimi Kim, Jeonghee Lee + Show 6 more

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https://doi.org/10.1038/s41598-019-39747-5

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Abstract

It is unclear whether dietary lutein/zeaxanthin intake in colorectal cancer is associated with microRNA processing involved in DICER1 cleavage for messenger RNA translation. We investigated whether dietary lutein/zeaxanthin intake affects colorectal cancer risk in patients with a DICER1 rs3742330 polymorphism. In this hospital-based case-control study, we recruited 923 colorectal cancer patients and 1,846 controls based on eligibility criteria, a semiquantitative food frequency questionnaire and the DICER1 rs3742330 genotype. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression adjusted for confounders. The highest quartile of lutein/zeaxanthin consumption was inversely associated with a reduced colorectal cancer risk (OR, 95% CI = 0.25, 0.18–0.36). Carrying G allele (AG + GG) showed a significantly reduced colorectal cancer incidence compared with that of AA carriers (OR, 95% CI = 0.71, 0.55–0.91). Those carrying the G allele (AG + GG) along with high lutein/zeaxanthin consumption were markedly associated with a decreased colorectal cancer risk (OR, 95% CI = 0.32, 0.22–0.46, P for interaction = 0.018), particularly for rectal cancer (OR, 95% CI = 0.24, 0.15–0.39, P for interaction = 0.004), compared with that of AA carriers with low lutein/zeaxanthin intakes. In conclusion, colorectal cancer risk was related to an interactive effect between dietary lutein/zeaxanthin intake and the DICER1 rs3742330 polymorphism.

Highlights

Many investigators have revealed the importance of microRNAs in cancer initiation and progression via their effects in silencing tumor suppressive and oncogenic messenger RNAs13. miRNAs are small noncoding regions that are linked to both mRNA translation and RNA silencing[14]
A single nucleotide polymorphism (SNP) of rs3742330, which is related to miRNA synthesis, is located in the 3′-untranslated region (UTR) of DICER1 on 14q32, and its regulation has become important in association with CRC risk[19,20]
The present study showed an association between dietary lutein/zeaxanthin intake and CRC risk among those with the DICER1 rs3742330 genotype in a Korean population

Summary

Introduction

Many investigators have revealed the importance of microRNAs (miRNAs) in cancer initiation and progression via their effects in silencing tumor suppressive and oncogenic messenger RNAs (mRNAs)13. miRNAs are small noncoding regions that are linked to both mRNA translation and RNA silencing[14]. MiRNAs are small noncoding regions that are linked to both mRNA translation and RNA silencing[14]. DICER1 is involved in the processing necessary for miRNA biogenesis. Dicer is an essential enzyme for miRNA biogenesis and maturation, enabling mRNA to repress gene expression[16]. The miRNAs processed by DICER1 have been reported to mediate ovarian cancer, breast cancer, and CRC through carcinogenic mechanisms such as cellular proliferation, apoptosis, and differentiation[17,18]. A single nucleotide polymorphism (SNP) of rs3742330, which is related to miRNA synthesis, is located in the 3′-untranslated region (UTR) of DICER1 on 14q32, and its regulation has become important in association with CRC risk[19,20]. This study investigated whether lutein/zeaxanthin intake shows an interaction with DICER1 rs3742330 in relation to CRC risk

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