Abstract
The effects of l-cysteine (1 and 2%) on the antioxidative system were examined in rats with d-galactosamine (d-GalN)-induced injury. These rats showed increases in serum antioxidative enzyme and hepatic thiobarbituric acid reactive substances (TBARS) activities, with decreased hepatic/serum glutathione (GSH) levels and GSH-related enzyme activities. However, l-cysteine supplementation resulted in a decrease of hepatic TBARS levels, and increased catalase and serum GSH levels. The activities of serum enzymes in rats receiving 2% l-cysteine were significantly (p<0.05) lower than in d-GalN-injected group rats, and similar to levels in control group rats without acute liver injury. In addition, 2% l-cysteine increased the glutathione reductase activity and decreased the serum TBARS level in liver injury group rats. Dietary l-cysteine, especially at a 2% level, exerts a hepatoprotective effect by alteration of the GSH level and antioxidative enzyme activities.
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