Dietary interventions as a neuroprotective therapy for the delay of the onset of cognitive decline in older adults: an umbrella review protocol.

Abstract

Review question and Objective Are individual dietary interventions effective in delaying the onset of cognitive decline in older adults? The objective of this umbrella review is to determine the effectiveness of individual dietary interventions in delaying the onset of cognitive decline in older adults. Inclusion criteria Types of participants Inclusion criteria This umbrella review will consider systematic reviews of older adult humans with a mean age 60 years or older without clinically-diagnosed dementia/ Alzheimer's Disease at baseline, including those who have reported difficulties with memory (memory complainers) and/or with mild cognitive impairment as a result of the ageing process. Exclusion criteria The umbrella review will not include; participants with a mean age of less than 60 years participants with clinically-diagnosed dementia/ Alzheimer's Disease at baseline participants with cognitive impairment due to brain injury studies of participants with vascular dementia studies using animal models. Types of intervention(s) Inclusion criteria This umbrella review will consider systematic reviews that have evaluated the effects of administration of any dose of the individual dietary interventions listed below for any duration. Dietary interventions included in this review are alpha- lipoic acid acetyl-L-carnitine polyphenols choline inositol compounds omega-3 polyunsaturated fatty acids. Exclusion criteria This umbrella review will not consider systematic reviews of; combinations of individual dietary components or supplements vitamin supplements studies that combined drugs with a dietary intervention studies of whole of diet approaches. Types of outcomes Inclusion criteria Primary outcomes This umbrella review will consider systematic reviews that include the following primary outcome measures: cognitive function (as measured by psychometric tests). Cognitive function tests diagnostic of mild cognitive impairment and Alzheimer's Disease include, but are not limited to, Alzheimer’s Disease Assessment Subscale, Clinical Dementia Rating Scale, Cambridge Cognitive Examination, Mini Mental State Examination, Telephone Interview of Cognitive Status. Secondary outcomes This umbrella review will consider systematic reviews that include the following secondary outcome measures: analysis from brain imaging techniques including, volumetric cranial magnetic resonance imaging scan, uptake of the radioligand C-Pittsburgh compound B deposits in the brain by positron emission tomography TRUNCATED AT 350 WORDS