Abstract
It was previously reported that dietary intake is an important trigger for systemic inflammation and one of the lifestyle factors for the development of cardiovascular diseases. The aim of this study was to evaluate the association between Dietary Inflammatory Index (DII) score and body weight, blood pressure, lipid profile and leptin in an Indonesian population. This was a cross-sectional study conducted in 503 Indonesian adults. The DII score was calculated based on data of 30 nutrients and food components. Anthropometric profile, blood pressure, lipid profile, and leptin were measured. The association of these variables with the DII score was analyzed. The DII score was not associated with body weight, body mass index (BMI), body fat, waist circumference, hip circumference, systolic and diastolic blood pressure, triglycerides, and high-density lipoprotein (HDL) (both unadjusted and after adjustment for covariates). However, plasma leptin concentration was significantly associated with the DII score (B = 0.096, p = 0.020). Plasma leptin also increased significantly across tertiles of the DII score (ANCOVA, p = 0.031). This positive association between the DII score and plasma leptin concentration suggests a role for the inflammatory properties of the diet in regulating adipose tissue inflammation.
Highlights
Obesity affects millions of adults and children and this state of over-nutrition is responsible for an increasing economic and health burden worldwide [1,2]
We found that Dietary Inflammatory Index (DII) score was not correlated with any of the anthropometric measures, blood pressure or lipid profile
We showed that the DII score was positively associated with plasma leptin concentration after adjustment for age, sex, body mass index (BMI), energy intake, and physical activity
Summary
Obesity affects millions of adults and children and this state of over-nutrition is responsible for an increasing economic and health burden worldwide [1,2]. Adiposity is associated with increased risk for non-communicable diseases (NCDs) such as type 2 diabetes mellitus, dyslipidemia, heart disease, and hypertension [1]. One of the mechanisms which may explain the interaction between obesity and the development of NCDs is systemic and adipose tissue inflammation [3,4]. A reduction in anti-inflammatory immune cells in adipose tissue of individuals with obesity has been reported [5,6]. This combination leads to an inflammatory state in adipose tissue as well as the circulation of individuals with obesity [4]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
