Abstract
Background: Soluble Klotho (S-Klotho) is an aging suppressor with a close link with inflammation. However, it is still unknown whether the dietary inflammatory potential is associated with S-Klotho plasma level. We aimed to investigate the association of the Dietary Inflammatory Index (DII) with S-Klotho plasma levels in middle-aged sedentary adults. Methods: 73 middle-aged sedentary adults (40–65 years old) participated in the present study. DII was determined from 28 dietary items obtained by 24 h recalls and food frequency questionnaires. The S-Klotho plasma levels were measured using a solid-phase sandwich enzyme-linked immunosorbent assay. Results: a weak positive association was observed between DII and S-Klotho plasma levels (β = 52.223, R2 = 0.057, p = 0.043), which disappeared after controlling for body mass index (p = 0.057). Conclusions: A pro-inflammatory dietary pattern measured with the DII was slightly and positively associated with S-Klotho plasma levels in middle-aged sedentary adults.
Highlights
Human life expectancy is projected to increase at least 65% for women and 85% for men in the following years in developed countries [1]
Previous evidence suggests a close link between chronic inflammation during the aging process and the incidence of several age-associated chronic diseases in humans [2,3]
The Dietary Inflammatory Index (DII) has been developed, a dietary tool which determines the inflammatory potential of an specific individual diet [9]
Summary
Human life expectancy is projected to increase at least 65% for women and 85% for men in the following years in developed countries [1]. The rise of non-communicable chronic disease prevalence has increased health care costs [1] In this sense, previous evidence suggests a close link between chronic inflammation during the aging process and the incidence of several age-associated chronic diseases in humans (i.e., cardiovascular diseases, diabetes mellitus, cancer, inflammatory bowel disease, and asthma, among others) [2,3]. Soluble Klotho (S-Klotho) is an aging suppressor with a close link with inflammation It is still unknown whether the dietary inflammatory potential is associated with S-Klotho plasma level. Index (DII) with S-Klotho plasma levels in middle-aged sedentary adults. Results: a weak positive association was observed between DII and S-Klotho plasma levels (β = 52.223, R2 = 0.057, p = 0.043), which disappeared after controlling for body mass index (p = 0.057).
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