Abstract
Serum β-glucuronidase activity is shown to differ quantitatively in the following strains of mice, listed in order of increasing activity: C3H, C57BL 6 < BALB c , DBA 2 , ICR < SENCAR, A He . The level of the enzyme in the murine strains is shown to correlate with the urinary excretion of 17-ketosteroids, which in turn reflects the endogenous level of androgens. Dietary calcium d-glucarate, an in vivo β-glucuronidase inhibitor, reduced the steady state level of both β-glucuronidase and 17-ketosteroid excretion in the highly susceptible A He and SENCAR strains to that of strains known to be resistant to chemical carcinogenesis. Sensitivity of the A He strain is significantly reduced by dietary calcium glucarate, which is shown to inhibit DNA binding and the induction of pulmonary adenomas by benzo[ a]pyrene.
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