Dietary Fresh and Boiled Mangkokan Leaves (Nothopanax Scutellarius) Normalized Body Weight, Serum Lipid Profile and Malondialdehyde in Metabolic Syndrome Rats

Devi Elvina Rachma,Retno Murwani,Achmad Zulfa Juniarto

doi:10.12944/crnfsj.8.3.19

Devi Elvina Rachma, Retno Murwani + Show 1 more

Open Access

https://doi.org/10.12944/crnfsj.8.3.19

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Abstract

The antioxidant activity of Nothopanax scutellarius (Burm. f.) Merr, an edible plant, can prevent oxidative stress in metabolic syndrome (MetS). Thus, our research aimed to study the effect of dietary inclusion of fresh or boiled N. scutellarius on body weight and biochemical markers of Wistar rats with MetS. Twenty-four male Wistar rats were divided randomly into four groups, i.e., normal control group, high-fat-high-fructose diet (HFFD) group, fresh N. scutellarius (FNs) group, and boiled N. scutellarius (BNs) group. The normal control group was fed only a standard diet during the entire experiment. High-fat and high-fructose (HFHFr) diet accompanied with 20% fructose in drinking water to induce MetS was given to the HFFD, FNs, and BNs groups for 29 days. This was followed by a 29-day intervention diet in which standard normal diet, fresh N. scutellarius-containing standard diet, and boiled N. scutellarius-containing standard diet were given to the HFFD, FNs, and BNs groups, respectively. HFHFr diet significantly (p<0.05) raised fasting blood glucose (FBG), serum triglyceride, total cholesterol, LDL-cholesterol, and malondialdehyde (MDA), and significantly (p<0.05) reduced HDL-cholesterol. After 29 days on the intervention diet, serum triglycerides, total cholesterol, and LDL-cholesterol levels were found to decrease, and HDL-cholesterol levels were found to increase significantly (p<0.05). Thus, it can be concluded that dietary intake of N. scutellarius for 29 days can improve MetS components, i.e., FBG, serum lipid profile, and MDA, similar to those seen in rats on a normal control diet.

Highlights

Metabolic syndrome (MetS) is characterized by conditions of hyperglycemia, decreased serum highdensity lipoprotein, increased serum triglycerides, abdominal obesity, and high blood pressure
People with metabolic syndrome (MetS) have a higher risk of suffering degenerative disease such as diabetes mellitus type 2 (DM-2) and cardiovascular diseases because of oxidative stress conditions.[4]
Induction of metabolic syndrome (MetS) by feeding a high-fat high fructose diet accompanied by fructose drinking water (HFHFr diet) in rats for 29 days can fulfill three out of the five criteria of MetS

Summary

Introduction

Metabolic syndrome (MetS) is characterized by conditions of hyperglycemia, decreased serum highdensity lipoprotein, increased serum triglycerides, abdominal obesity, and high blood pressure. When three out of the five criteria are met, the condition is categorized as MetS.[1] The prevalence of MetS increases every year, with approximately 20%–25% of adults worldwide experiencing MetS2 and cases in Indonesia exceeded 13.3%.3. People with MetS have a higher risk of suffering degenerative disease such as diabetes mellitus type 2 (DM-2) and cardiovascular diseases because of oxidative stress conditions.[4]. Excessive fructose consumption increase glucose metabolism in the liver that can accumulate triglyceride and cholesterol and induce insulin resistance.[1,8]

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