Abstract
Current evidence from randomised controlled trials on the effects of dietary fibre intake on breast cancer risk is inconsistent. We conducted a meta-analysis to determine the effectiveness of dietary fibre intake in reducing breast cancer risk. We searched for prospective and case-control studies on dietary fibre intake and breast cancer risk in the English language through March 2016. Twenty-four epidemiologic studies obtained through the PubMed, Embase, Web of Science, and Cochrane Library databases were systematically reviewed. A random-effects model was used to compute the pooled risk estimates by extracting the risk estimate of the highest and lowest reported categories of intake from each study. The meta-analyses showed a 12% decrease in breast cancer risk with dietary fibre intake. The association between dietary fibre intake and breast cancer risk was significant when stratified according to Jadad scores, study types, and menopause status. Dose-response analysis showed that every 10 g/d increment in dietary fibre intake was associated with a 4% reduction in breast cancer risk, and little evidence of publication bias was found. Thus, dietary fibre consumption is significantly associated with a reduced risk of breast cancer, particularly in postmenopausal women.
Highlights
Breast carcinoma is the most common carcinoma in women worldwide
Dose-response analysis showed that every 10 g/d increment in dietary fibre intake was associated with a 4% reduction in breast cancer risk, and little evidence of publication bias was found
This manuscript aimed to clarify the association between dietary fibre intake and the risk of breast cancer
Summary
Breast carcinoma is the most common carcinoma in women worldwide. Ecological and migrant studies have provided strong evidence that environmental factors, including lifestyle and dietary factors, are related to breast carcinoma risk [1,2,3]. Epidemiological studies have shown conflicting results for the relationship between intake of dietary fibre and breast cancer. There have been a lot of recent prospective cohort studies [7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22] on dietary fibre intake and breast cancer, and most of the results show that the association between the two is not significant. Due to the difficulties in obtaining precise estimates of intakes of dietary fibre and owing to the limited heterogeneity of fibre intake within geographically confined populations, the results of these analytical epidemiological studies were conflicting
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