Abstract
BackgroundSince Fuchs' report in 1999, the reported protective effect of dietary fiber from colorectal carcinogenesis has led many researchers to question its real benefit. The aim of this study is to evaluate the association between diet, especially dietary fiber and fat and colorectal cancer in Japan.MethodsA multiple regression analysis (using the stepwise variable selection method) was performed using the standardized mortality ratios (SMRs) of colon and rectal cancer in 23 Japanese prefectures as objective variables and dietary fiber, nutrients and food groups as explanatory variables.ResultsAs for colon cancer, the standardized partial correlation coefficients were positively significant for fat (1,13, P = 0.000), seaweeds (0.41, P = 0.026) and beans (0.45, P = 0.017) and were negatively significant for vitamin A (-0.63, P = 0.003), vitamin C (-0.42, P = 0.019) and yellow-green vegetables (-0.37, P = 0.046). For rectal cancer, the standardized partial correlation coefficient in fat (0.60, P = 0.002) was positively significant. Dietary fiber was not found to have a significant relationship with either colon or rectal cancers.ConclusionsThis study failed to show any protective effect of dietary fiber in subjects with a low fat intake (Japanese) in this analysis, which supports Fuchs' findings in subjects with a high fat intake (US Americans).
Highlights
It is currently believed that dietary fiber and dietary fat are the most significantly associated dietary factors in colorectal carcinogenesis [1,2,3]
Fuchs' results generated many points of controversy against the study, such as the inaccuracy of the dietary survey; the basic values for fiber may not merit such analysis; and the possible effect of fiber consumed early in life on the risk of colorectal cancer cannot be ruled out; no assessment of colonic function was taken into consideratioon [6] and so on
To evaluate the association between diet and colorectal cancer, we examined the correlation between dietary intake around 1990 and the standardized mortality ratios (SMRs) of colon and rectal cancer between 1995 and 1997 in 23 Japanese prefectures
Summary
It is currently believed that dietary fiber and dietary fat are the most significantly associated dietary factors in colorectal carcinogenesis [1,2,3]. Since Fuchs' report [5] in 1999, the reported protective effect of dietary fiber on colorectal carcinogenesis has led many researchers to question its real benefit. BMC Cancer 2001, 1:14 http://www.biomedcentral.com/1471-2407/1/14 colorectal carcinogenesis, as the protective effects of dietary factors on carcinogenesis may be based upon the balance of the overall diet, and on the interaction of specific dietary components, such as dietary fiber, nutrients and other foods. Since Fuchs' report in 1999, the reported protective effect of dietary fiber from colorectal carcinogenesis has led many researchers to question its real benefit. The aim of this study is to evaluate the association between diet, especially dietary fiber and fat and colorectal cancer in Japan
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
