Abstract
Single nucleotide polymorphisms (SNPs) within the transcription factor 7-like 2 ( TCF7L2 ) gene are well known risk variants for type 2 diabetes (1). The best studied SNP is rs7903146, which is additionally associated with insulin secretion (2) and BMI (3). We furthermore reported that this variant influenced weight loss during the Tubingen Lifestyle Intervention Program (TULIP) such that carriers of the nonrisk CC alleles lost more weight than carriers of XT alleles (4). The TULIP program consists of exercise and diet intervention with decreased intake of fat and increased intake of fibers (participants were instructed to eat at least 15 g fiber per 1,000 kcal). However, a recent report (1) from the Diabetes Prevention Program (DPP) failed to replicate the association of TCF7L2 SNP rs7903146 with successful weight loss during lifestyle intervention. The authors speculated that …
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