Abstract
Ferulic acid (FA) is a phenolic compound that has antioxidant, hepatoprotective, anticarcinogenic, anti-inflammatory, antiallergic, antimicrobial, antiviral, and vasodilatory effects. This study was conducted to explore the effects of dietary FA supplementation on antioxidant capacity and lipid metabolism in weaned piglets. Eighteen 21-day-old castrated male DLY (Duroc × Landrace × Yorkshire) weaned piglets were randomly divided into control, 0.05%, and 0.45% FA groups. The results showed that, in serum, CAT and T-SOD activities and content of HDL-C were increased, but the content of MDA and the activities of T-CHO and LDL-C were decreased, by FA supplementation. In liver, dietary FA supplementation increased CAT, T-SOD, and GSH-PX activities and upregulated the mRNA levels of SOD1, SOD2, CAT, GST, GPX1, GR, Nrf2, HSL, CPT1b, and PPARα but decreased the contents of MDA and TG. Furthermore, dietary FA supplementation increased the protein level of Nrf2, HO-1, and NQO-1. In longissimus dorsi muscle, dietary FA supplementation increased the activity of T-SOD and the mRNA abundance of SOD1, SOD2, CAT, GST, GPX1, GR, and Nrf2 but decreased the contents of MDA and T-CHO. Additionally, dietary FA supplementation increased the protein expressions of Nrf2, HO-1, and NQO1. Together, our data suggest that FA could improve antioxidant capacity and lipid metabolism in weaned piglets.
Highlights
The content and composition of lipids are in dynamic balance in the body, and the control of lipids by the body is carried out through the lipid metabolism pathway [1]
The disturbance of lipid metabolism causes the dynamic balance of fat deposition and consumption to be disturbed, and it may lead to the ectopic deposition of fat, which may affect the health of animals
Dyslipidemia can lead to fatty deposits in the liver that bring about nonalcoholic fatty liver disease and cardiovascular disease [30,31]
Summary
The content and composition of lipids are in dynamic balance in the body, and the control of lipids by the body is carried out through the lipid metabolism pathway [1]. Lipid metabolism involves a variety of physiological processes, including energy metabolism, transport of lipid-soluble substances, and synthesis of hormones; it is the process of synthesis, decomposition, digestion, absorption, elimination, and transportation of lipids under the action of various enzymes. Lipid metabolism includes the metabolism of fatty acids, triglycerides, and cholesterol. Fatty acid metabolism is the basis of the metabolism of other lipids, and triglyceride and cholesterol metabolism are associated with lipid transporters HDL and LDL [2,3,4]. Normal lipid metabolism plays an important role in maintaining lipid balance in the body. The production and elimination of Nutrients 2020, 12, 3811; doi:10.3390/nu12123811 www.mdpi.com/journal/nutrients
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